Acetic Acid → HCID 54164352, compound

HRID 378974Notes

Reaction equation

HRID 378974 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][C:14]=2[CH:15]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CN.C(O)C.C(O)(=O)C.[N+:32]([CH3:35])([O-:34])=[O:33]>CO>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH:15]=[CH:35][N+:32]([O-:34])=[O:33])=[CH:17][CH:18]=[CH:19][C:20]=2[O:21][CH3:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

7

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 6329MethylamineHCID 6375NitromethaneHCID 21697292HCID 21697292, compound

Product 1

HCID 54164352HCID 54164352, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Operating analogously to example 2 using 2-(5-phenylpentyloxy)-3-methoxy-benzaldehyde (1 g, 3.35 mmoles), obtained as described in example 12, 8.03M methylamine in ethanol (0.088 ml, 0.7035 mmoles), acetic acid (0.04 ml, 0.7035 mmoles) and nitromethane (0.198 ml, 3.685 mmoles) in methanol (5 ml), 0.56 g of the title product was obtained (yield: 49%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-cd5f292f5a484da6849c6c6c5462afba
Source dataset
uspto-grants-2001_10
Patent number
US06297257B1

Reaction notes

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