Benzyl Bromide → HCID 20693375, compound

HRID 380073Notes

Reaction equation

HRID 380073 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7][CH2:8][S:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:1]([O:5][C:6](=[O:17])[CH2:7][CH2:8][S:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 20693380HCID 20693380, compound

Product 1

HCID 20693375HCID 20693375, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture solution of the compound prepared in Example 1(1) (3.29 g), benzyl bromide (2.3 ml), potassium carbonate (3.58 g) and dimethylformamide (15 ml) was stirred overnight at room temperature. The reaction solution was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the title compound (2.20 g) having the following physical data.

Workup

  1. extractionThe reaction solution was extracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-9c7076cea8bb42deafce700fa8a5f7cc
Source dataset
uspto-grants-2001_10
Patent number
US06300514B1

Reaction notes

Loading…