反应详情

温度

50 °C

An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol %), 2-(di-tert-butylphosphino)biphenyl (6.0 mg, 0.020 mmol, 2.0 mol %), 3-acetylphenylboronic acid (246 mg, 1.5 mmol), and potassium fluoride (173 mg, 3.0 mmol). The tube was evacuated and backfilled with argon, and THF (1 mL) and 3-chloropyridine (0.095 mL, 1.0 mmol) were added through a rubber septum. The tube was sealed with a teflon screwcap, and the reaction mixture was heated to 50° C. with stirring until the starting aryl chloride had been completely consumed as judged by GC analysis. The reaction mixture was then diluted with ether (30 mL) and poured into a separatory funnel. The mixture was washed with water (20 mL), and the aqueous layer was extracted with ether (20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography on silica gel to afford 181 mg (92%) of the title compound.

1. customAn oven dried resealable Schlenk tube
2. customwas evacuated
3. customThe tube was evacuated
4. additionwere added through a rubber septum
5. customhad been completely consumed
6. additionThe reaction mixture was then diluted with ether (30 mL)
7. additionpoured into a separatory funnel
8. washThe mixture was washed with water (20 mL)
9. extractionthe aqueous layer was extracted with ether (20 mL)
10. washThe combined organic layers were washed with brine (20 mL)
11. dry with materialdried over anhydrous magnesium sulfate
12. filtrationfiltered
13. concentrationconcentrated
14. customThe crude material was purified by flash chromatography on silica gel