反应详情

Sodium hydride (88 mg, 60% wt.) was added portionwise to a solution of 4-BOC-piperazinone (400 mg) in DMF (10 ml). The reaction mixture was stirred for 1 h, and then benzyl bromide (262 μl) was added dropwise and the mixture stirred at room temp for 16 h. The reaction was quenched with methanol and diluted with water, and then extracted with EtOAC. The organic extracts were concentrated in vacuo and the residue was purified by chromatography (silica, 20% ether/hexane as eluent) to give the sub-title compound (429 mg).

1. stirringthe mixture stirred at room temp for 16 h
2. customThe reaction was quenched with methanol
3. additiondiluted with water
4. extractionextracted with EtOAC
5. concentrationThe organic extracts were concentrated in vacuo
6. customthe residue was purified by chromatography (silica, 20% ether/hexane as eluent)