反应详情

5-Chloro-1-phenyl-1H-tetrazole (1.00 g, 5.54 mmol), butylamine (0.547 mL, 5.54 mmol), and diisopropylethylamine (1.48 mL, 8.31 mmol) were dissolved in DMF (5 mL), and stirred overnight at room temperature. Reaction diluted with EtOAc and washed with water and brine. Organic layer dried with Na2SO4, filtered, and concentrated in vacuo. Residue purified by flash chromatography on silica gel eluting with 35% EtOAc/Hexanes to afford the desired product as a white solid (625 mg, 52%). m/e (DCI) 218 (MH+)

1. customReaction
2. washwashed with water and brine
3. dry with materialOrganic layer dried with Na2SO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customResidue purified by flash chromatography on silica gel eluting with 35% EtOAc/Hexanes