反应详情

温度

120 °C

To a solution of 4-iodophenol (200 mg) in dimethylsulfoxide (1 ml), 218 mg of 2-chloro-1-fluoro-4-(trifluoromethyl)benzene and 251 mg of potassium carbonate were added, and the reaction solution was stirred at 120° C. for 3 hours. The reaction solution was cooled, ethyl acetate was added, the insoluble matter was filtered off, and the filtrate was washed with water and a saturated saline solution and dried over an anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: hexane/ethyl acetate (98:2-80/20)) to afford the title compound as a colorless oil.

1. temperatureThe reaction solution was cooled
2. filtrationthe insoluble matter was filtered off
3. washthe filtrate was washed with water
4. dry with materiala saturated saline solution and dried over an anhydrous magnesium sulfate
5. distillationThe solvent was distilled off under reduced pressure
6. customthe residue obtained
7. customwas purified by silica gel column chromatography (eluent: hexane/ethyl acetate (98:2-80/20))