反应详情

4-(3-Nitro-2-methoxy-phenyl)-thiophene-2-carboxylic acid 51a (400 mg, 1.45 mmol) was dissolved in 30 mL of ethyl acetate followed by addition of 100 mg of palladium on carbon and ammonium formate (360 mg, 5.8 mmol). The mixture was heated to reflux for 3 hours. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was filtered to remove palladium on carbon and concentrated under reduced pressure to obtain the title compound 4-(3-amino-2-methoxy-phenyl)-thiophene-2-carboxylic acid 51b (410 mg) as a brown oil, which was directly used in the next step.

1. temperatureThe mixture was heated
2. temperatureto reflux for 3 hours
3. filtrationThe mixture was filtered
4. customto remove palladium on carbon
5. concentrationconcentrated under reduced pressure