反应详情

温度

80 °C

To a solution of racemic ethyl 4-amino-3-methoxypiperidine-1-carboxylate (1 part by mole) in DMF were added benzyl bromide (about 2.2 part by mole), potassium carbonate (about 2.4 part by mole) and potassium iodide (about 0.2 part by mole) respectively. The reaction was heated to about 80° C. After about 6 hours, the reaction was slowly diluted with water (about 12 parts by volume) and extracted with, for example, ethyl acetate. The organic layer was washed with brine and then dried over anhyh. Na2SO4. Subsequent filtration and concentration of the solvent provided the 1 as the yellow-orange oil (1 part by mole).

1. extractionextracted with, for example, ethyl acetate
2. washThe organic layer was washed with brine
3. customdried over anhyh
4. filtrationSubsequent filtration and concentration of the solvent
5. customprovided the 1 as the yellow-orange oil (1 part by mole)