1,1'-Carbonyldiimidazole → HCID 59526324, compound

HRID 385966Notes

Reaction equation

HRID 385966 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[C:4]([CH3:12])[N:3]=1.[C:13](N1C=CN=C1)(N1C=CN=C1)=[O:14]>CN(C)C=O.C(OCC)(=O)C>[Cl:1][C:2]1[N:3]=[C:4]([CH3:12])[C:5]([C:6]2[O:7][C:13](=[O:14])[NH:9][N:8]=2)=[CH:10][CH:11]=1

Participants

5

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 595262086-Chloro-2-methylnicotinohydrazide

Product 1

HCID 59526324HCID 59526324, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

6-Chloro-2-methylnicotinohydrazide (60 mg, 0.32 mmol) and 1,1′-carbonylbis(1H-imidazole) (58 mg, 0.36 mmol) were taken up in dimethylformamide (1.6 ml). The reaction was heated overnight to 60° C. It was then allowed to cool to room temperature, taken up in ethyl acetate, and washed with water. The organic layer was concentrated under reduced pressure to afford the title compound.

Workup

  1. temperatureThe reaction was heated overnight to 60° C
  2. washwashed with water
  3. concentrationThe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5fe1a4378f904037b7d8f81c20a2376a
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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