反应详情

To a solution of 2-chloro-4-ethoxypyrimidine (3 g, 19 mol) in THF (410 mL) was added pyrrolidine (2.7 g, 38 mmol) and Et3N (5.8 g, 57 mmol) and the reaction mixture was heated to reflux overnight. The solvent was evaporated and the residue was partioned between water and EtOAc. The aqueous phase was extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered, and concentrated to give the title compound.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux overnight
3. customThe solvent was evaporated
4. extractionThe aqueous phase was extracted with EtOAc
5. dry with materialThe combined organic phases were dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated