Trifluoroacetic acid → HCID 59526009, compound

HRID 386130Notes

Reaction equation

HRID 386130 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[C:4]([F:12])[C:3]=1[C:13]1[S:17][C:16]([NH:18][C:19]2[N:20]=[N:21][C:22]([O:25]CC[Si](C)(C)C)=[CH:23][CH:24]=2)=[C:15]([C:32]([NH2:34])=[O:33])[CH:14]=1.C(O)(C(F)(F)F)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[F:12][C:4]1[CH:5]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:7]=[C:2]([F:1])[C:3]=1[C:13]1[S:17][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22](=[O:25])[NH:21][N:20]=2)=[C:15]([C:32]([NH2:34])=[O:33])[CH:14]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 59526380HCID 59526380, compound

Product 1

HCID 59526009HCID 59526009, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[2-(trimethylsilyl)ethoxy]pyridazin-3-yl}amino)thiophene-3-carboxamide (0.61 g, 1.20 mmol) was taken up in DCM (12 mL) and TFA (0.4 mL) was added. After 30 minutes at room temperature, saturated NaHCO3 was added. The resulting precipitate was collected by filtration and triturated in DCM to give the title compound as a yellow solid.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customtriturated in DCM

Sources & evidence

ORD record
ord-dc18678313c140459ad746d8104c75e9
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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