反应详情

温度

130 °C

Into a microwave vial was added 2-amino-5-(6-piperidin-1-ylpyridin-3-yl)thiophene-3-carbonitrile (225 mg, 0.79 mmol), 1-propanol (6.2 ml), and 25% sodium hydroxide (1.8 ml) and the mixture was heated in the microwave to 130° C. for 30 min. The reaction mixture was diluted with ethyl acetate and sodium bicarbonate to neutralize, extracted with ethyl acetate (3×100 mL), dried over magnesium sulfate, filtered and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with ethyl acetate/methanol to afford the title compound as a solid.

1. extractionextracted with ethyl acetate (3×100 mL)
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by column chromatography on silica gel
6. washeluting with ethyl acetate/methanol