反应详情

温度

140 °C

A mixture of 2-fluoro-4-iodobenzonitrile (4000 mg, 16.19 mmol), 5-chloro-4-hydroxypyridin-2(1H)-one (2357 mg, 16.19 mmol), 4,7-dimethoxy-1,10-phenanthroline (778 mg, 3.24 mmol), copper(I) iodide (617 mg, 3.24 mmol) and potassium carbonate (4476 mg, 32.4 mmol) in DMSO (40 mL) was stirred at 140° C. under N2 for 3 hrs. After cooling to room temperature, the reaction mixture was diluted with H2O (50 mL) and 1N HCl was added to adjust the pH to ˜2 (pH paper). The resulting mixture was extracted with EtOAc (400 mL, 2×). The combined extracts were dried (Na2SO4) and evaporated under reduced pressure to give black oil. The residue was purified by flash chromatography on silica gel (0-7% MeOH/CH2Cl2) to give brown oil (3.2 g, 43.3%). MS (ESI) 265 (M+H).

1. temperatureAfter cooling to room temperature
2. additionwas added
3. extractionThe resulting mixture was extracted with EtOAc (400 mL, 2×)
4. dry with materialThe combined extracts were dried (Na2SO4)
5. customevaporated under reduced pressure
6. customto give black oil
7. customThe residue was purified by flash chromatography on silica gel (0-7% MeOH/CH2Cl2)