反应详情

To the product of Step B, 1-b, (7.06 g, 24.7 mmol) in EtOH (40 mL) was added NaOEt (20.3 mL, 54.4 mmol, 21 wt in EtOH). The reaction was heated to reflux for 3 h and then cooled before the addition of aq HCl (28 mL, 2 M) followed by dilution with EtOAc and brine. The solution was extracted three times with EtOAc and dried (Na2SO4) to afford the title compound, 1-1, which was used without further purification to prepare Intermediate 4. HPLC/MS: 240.1 (M+1); Rt=2.22 min.

1. temperatureThe reaction was heated
2. temperatureto reflux for 3 h
3. extractionThe solution was extracted three times with EtOAc
4. dry with materialdried (Na2SO4)