反应详情

660 mg of methyl[2-(2-bromo-4-trifluoromethylphenyl)ethyl](1-propylbutyl)carbamate are dissolved under an inert atmosphere in 15 cm3 of dichloromethane at a temperature close to 10° C. 575 mg of 4-dimethylaminopyridine are added to the reaction mixture. 1.32 cm3 of trifluoromethanesulfonic anhydride in solution in 2 cm3 of anhydrous dichloromethane are poured into the reaction mixture over 5 min. The reaction mixture is kept stirring for 15 h at a temperature close to 20° C. 20 cm3 of a saturated aqueous solution of sodium hydrogen carbonate are added to the reaction medium. This stirring is continued for 30 min, then 20 cm3 of dichloromethane are added to the mixture. The organic phase is decanted then washed successively with 100 cm3 of a 0.1M aqueous solution of hydrochloric acid and 20 cm3 of a saturated aqueous solution of sodium hydrogen carbonate. Next, the organic phase is dried then concentrated using a rotary evaporator under reduced pressure (5 kPa). The residual solid is then purified by filtration through silica (silica 60—particle size 15-40 μm—eluent: 50% ethyl ethyl acetate/50% cyclohexane). The organic phase is concentrated under reduced pressure (5 kPa). 519 mg of 5-bromo-7-trifluoromethyl-2-(1-propylbutyl)-3,4-dihydroisoquinoline-1(2H)-one are obtained in the form of a yellow oil.

1. customclose to 10° C
2. customclose to 20° C
3. waitThis stirring is continued for 30 min
4. customThe organic phase is decanted
5. washthen washed successively with 100 cm3 of a 0.1M aqueous solution of hydrochloric acid and 20 cm3 of a saturated aqueous solution of sodium hydrogen carbonate
6. customNext, the organic phase is dried
7. concentrationthen concentrated
8. customa rotary evaporator under reduced pressure (5 kPa)
9. filtrationThe residual solid is then purified by filtration through silica (silica 60—particle size 15-40 μm—eluent: 50% ethyl ethyl acetate/50% cyclohexane)
10. concentrationThe organic phase is concentrated under reduced pressure (5 kPa)