反应详情

温度

50 °C

After adding dimethylformamide (4 ml), tert-butyl 4-(bromomethyl)-1-piperidine carboxylate (708 mg) and potassium carbonate (467 mg) to 4-(4-amino-3-fluorophenoxy)-6-cyano-7-hydroxyquinoline (500 mg), the mixture was heated at 50° C. for 4 hours. Water was added to the reaction solution, extraction was performed with ethyl acetate and the organic layer was washed with water and saturated saline in that order and then dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained crude product was purified by silica gel column chromatography (n-hexane:ethyl acetate) to obtain the title compound (398 mg).

1. washthe organic layer was washed with water and saturated saline in that order
2. dry with materialdried over anhydrous sodium sulfate
3. distillationthe solvent was distilled off under reduced pressure
4. customThe obtained crude product
5. customwas purified by silica gel column chromatography (n-hexane:ethyl acetate)