反应详情

温度

62.5 °C

To a mixture of 4-Methoxy-5-methyl-2-(4-nitro-phenoxy)-indan-1-one (1.8 gm, 0.0057 mole) and Triethyl silane (9.0 ml, 0.0564 mole), Trifluoroacetic acid (18 ml) was added at 20-25° C. The reaction mixture was heated to 60-65° C. for 3 hours and then poured into saturated Sodium bicarbonate solution. It was extracted with Ethylacetate (2×100 ml), dried over Sodium sulphate, distilled under vacuum to give a crude product which was purified by column chromatography using Ethyl acetate:Hexane (2:98) as a mobile phase. The collected fractions were distilled under vacuum to give 1.2 gm of desired product as a solid.

1. additionwas added at 20-25° C
2. extractionIt was extracted with Ethylacetate (2×100 ml)
3. dry with materialdried over Sodium sulphate
4. distillationdistilled under vacuum
5. customto give a crude product which
6. customwas purified by column chromatography
7. distillationThe collected fractions were distilled under vacuum