Benzaldehyde → HCID 67441412, compound

HRID 389938Notes

Reaction equation

HRID 389938 reaction equation
COP([CH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=2)[C:9](=[O:17])[O:8]1)(=O)OC.[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(N(CC)CC)C.O>O1CCCC1>[CH:18](=[C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=2)[C:9](=[O:17])[O:8]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 962WaterHCID 8471TriethylamineHCID 87401836HCID 87401836, compound

Product 1

HCID 67441412HCID 67441412, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of EXAMPLE 1C (4.6 g, 14.08 mmol) in anhydrous tetrahydrofuran (30 mL) was added benzaldehyde (0.71 mL, 7.4 mmol) and triethylamine (1.00 mL, 7.39 mmol). The reaction mixture was stirred at ambient temperature overnight. Water was added and the mixture stirred for 10 minutes. The precipitated solid was filtered and dried under vacuum to yield the title compound. MS (ESI) m/z 302 (M+H)+.

Workup

  1. stirringthe mixture stirred for 10 minutes
  2. filtrationThe precipitated solid was filtered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-9170f68ee52947488e12513a3e2796d9
Source dataset
uspto-grants-2013_02
Patent number
US08383623B2

Reaction notes

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