反应详情

温度

120 °C

A mixture of 5-fluoro-2-nitrobenzaldehyde (15.00 g, 0.089 mol), phenol (9.12 g, 0.098 mol), and K2CO3 (13.5 g, 0.089 mol) in 200 mL of DMF was heated at 120° C. for 50 min. The reaction mixture was cooled and concentrated in vacuo. To the residue was added EtOAc (500 mL) and H2O (500 mL). The layers were separated, and the EtOAc extract was concentrated. The residue was purified on silica gel using 20% EtOAc-hexane as eluent. The product containing fractions were combined and concentrated to yield a yellow oil which solidified on standing. This material was dissolved in a minimal quantity of EtOAc and hexane, and the resulting solution was cooled in a dry ice acetone bath. Filtration yielded 2-nitro-5-phenoxy-benzaldehyde as a light yellow solid. The filtrate was concentrated in vacuo to yield additional 2-nitro-5-phenoxy-benzaldehyde.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated in vacuo
3. additionTo the residue was added EtOAc (500 mL) and H2O (500 mL)
4. customThe layers were separated
5. extractionthe EtOAc extract
6. concentrationwas concentrated
7. customThe residue was purified on silica gel using 20% EtOAc-hexane as eluent
8. additionThe product containing fractions
9. concentrationconcentrated
10. customto yield a yellow oil which
11. temperaturethe resulting solution was cooled in a dry ice acetone bath
12. filtrationFiltration