Hydrochloric Acid → HCID 67322618, compound

HRID 390327Notes

Reaction equation

HRID 390327 reaction equation
[F:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.Cl>C(OCC)(=O)C>[F:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67323585HCID 67323585, compound

Product 1

HCID 67322618HCID 67322618, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 4-fluoro-4-pyridin-2-ylpiperidine-1-carboxylate (0.075 g, 0.27 mmol.) in 10 mL of ethyl acetate was saturated with gaseous HCl. After 1 h, the reaction was concentrated in vacuo to provide 2-(4-fluoropiperidin-4-yl)pyridine that gave a mass ion (ES+) of 181.1 for [M+H]+

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-ae02786b5a4a4d619b8c3ad96cdc256a
Source dataset
uspto-grants-2013_02
Patent number
US08383638B2

Reaction notes

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