反应详情

To a solution of 2-(BOC-amino)-5-bromopyridine (500 mg) in THF (20 mL) at 0° C. was added sodium hydride (88 mg) and the reaction stirred for 20 min. Then, iodoethane (0.18 mL) was added and the reaction stirred at room temperature for 16 h. The reaction was quenched with water (20 mL) and extracted into ethylacetate (3×20 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester as a white solid.

1. stirringthe reaction stirred at room temperature for 16 h
2. customThe reaction was quenched with water (20 mL)
3. extractionextracted into ethylacetate (3×20 mL)
4. dry with materialThe organic layers were dried (MgSO4)