反应详情

2.5 g (21 mmol) of 3-chloropropylisocyanate are dissolved in 150 mL of anhydrous THF and 6.4 mL (46 mmol) of Et3N. Once dissolved 3.4 mL (23 mmol) of decahydroquinoline are slowly added and it is refluxed for 18 h. AcOEt is then added and the resulting solution is sequentially washed with water, 1N HCl and brine. The organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure yielding 4.6 g of intermediate IIIf.1. Method B: tr: 3.58 min; m/z: 259

1. temperatureit is refluxed for 18 h
2. washthe resulting solution is sequentially washed with water, 1N HCl and brine
3. dry with materialThe organic phase is dried over anhydrous Na2SO4, it
4. filtrationis filtered
5. customthe solvent is evaporated under reduced pressure