反应详情

In 8 mL of dimethylformamide was dissolved 0.4 g of 6-chloro-3-(4-hydroxyphenoxy)-2-pyrazinecarbonitrile. After adding 0.5 ml of iodomethane and 0.89 g of potassium carbonate, the mixture thus obtained was stirred at room temperature for 30 minutes. The reaction mixture was added to a mixture of 10 mL of ethyl acetate and 30 mL of water, and the organic layer was separated. The organic layer was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Thus, 0.43 g of 6-chloro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile was obtained as a yellow-brown colored solid product.

1. customthe mixture thus obtained
2. customthe organic layer was separated
3. washThe organic layer was washed successively with water and saturated aqueous solution of sodium chloride
4. dry with materialdried on anhydrous magnesium sulfate
5. customthe solvent was removed under reduced pressure