反应详情

温度

50 °C

To a flask containing anhydrous 2-propanol (40 mL), hydrazine hydrate (4 mL, and anhydrous THF (60 mL), at room temperature, was added 2-{5-chloro-2-(3-methylisoxazol-5-ylmethoxy)benzyl]isoindole-1,3-dione (5 g, 13 mmol). The reaction was stirred at 50° C. for 3 h. The solids were filtered and washed with THF. The filtrate was concentrated, dissolved in ether (100 ml) and washed with 1N NaOH (1×) and brine, dried (MgSO4), filtered and concentrated to afford the title product as a solid.

1. filtrationThe solids were filtered
2. washwashed with THF
3. concentrationThe filtrate was concentrated
4. dissolutiondissolved in ether (100 ml)
5. washwashed with 1N NaOH (1×) and brine
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated