Hydrochloric Acid → HCID 22238046, compound

HRID 393566Notes

Reaction equation

HRID 393566 reaction equation
[CH3:1][O:2][CH:3]([O:6][CH3:7])[CH2:4][NH2:5].[N+:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17](Cl)(=[O:19])=[O:18])([O-:10])=[O:9].C(N(C(C)C)CC)(C)C.Cl>C(Cl)Cl>[CH3:1][O:2][CH:3]([O:6][CH3:7])[CH2:4][NH:5][S:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[N+:8]([O-:10])=[O:9])(=[O:18])=[O:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 155402-Nitrobenzenesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 89728Aminoacetaldehyde dimethyl acetal

Product 1

HCID 22238046HCID 22238046, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2,2-dimethoxyethylamine (2.61 g) in methylene chloride (100 ml) were added 2-nitrophenylsulfonylchloride (5.0 g) and diisopropylethylamine (5 ml) dropwise at −78° C. and the mixture was stirred for 10 minutes at room temperature. To the reaction mixture was added 1N hydrochloric acid and was extracted with chloroform. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate and was concentrated to give the title compound having the following physical data.

Workup

  1. extractionwas extracted with chloroform
  2. washThe organic layer was washed with a saturated aqueous solution of sodium chloride
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-92073b205657498ca10850391e9410c1
Source dataset
uspto-grants-2004_10
Patent number
US06809092B2

Reaction notes

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