反应详情

温度

80 °C

A mixture of 4-fluoro-2-methyl-5-nitrophenol (4.69 g, 27 mmol), benzyl bromide (3.59 ml, 30 mmol) and potassium carbonate (7.58 g, 55 mmol) in DMF (100 ml) was heated at 80° C. for 4 hours. The mixture was allowed to cool and diluted with water and stirred for 15 minutes. The precipitated product was collected by filtration, washed with water and dried to give 5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (6.4 g, 89%).

1. temperatureto cool
2. filtrationThe precipitated product was collected by filtration
3. washwashed with water
4. customdried