反应详情

3-Amino-6-methoxypyridine (12.41 g) and diethyl ethoxymethylene malonate (20.2 ml) in Dowtherm A (400 ml) were heated at reflux. under argon for 1 hour. The cooled reaction mixture was poured into pentane (1 litre). The precipitated solid was collected by filtration, washed with pentane and dried to afforded a solid (24.78 g, crude).

1. temperatureat reflux
2. customThe cooled reaction mixture
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with pentane
5. customdried
6. customto afforded a solid (24.78 g, crude)