反应详情

A mixture of 2-bromo-1-(4-bromophenyl)-1-ethanone (8.54 g, 30.7 mmol), potassium fluoride (8.92 g, 153 mmol) and 18-crown-6 ether (4.06 g, 15.3 mmol) in acetonitrile (170 ml) was refluxed for 7 hr. After evaporation, the mixture was dissolved in ethyl acetate (300 ml), washed with water (100 ml×2), and dried over magnesium sulfate. Removal of solvent gave 6.8 g of brown solid, which was chromatographed on a column of silica gel (600 g) eluting with ethyl acetate/hexane (1:10) to afford 5.00 g (75%) of the title compound as a pale yellow solid.

1. temperaturewas refluxed for 7 hr
2. customAfter evaporation
3. dissolutionthe mixture was dissolved in ethyl acetate (300 ml)
4. washwashed with water (100 ml×2)
5. dry with materialdried over magnesium sulfate
6. customRemoval of solvent