Triethylamine → HCID 18175008, compound

HRID 395580Notes

Reaction equation

HRID 395580 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[CH:15]=[C:14]([S:17](Cl)(=[O:19])=[O:18])[CH:13]=[CH:12]2)(=[O:3])[CH3:2].C([N:23](CC)CC)C.[OH-].[NH4+]>C(Cl)Cl>[NH2:23][S:17]([C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][CH:8]=[C:7]2[CH2:6][CH2:5][NH:4][C:1](=[O:3])[CH3:2])=[CH:12][CH:13]=1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 14923Ammonium HydroxideHCID 18175046HCID 18175046, compound

Product 1

HCID 18175008HCID 18175008, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.8 mmol of the compound obtained in Step B is dissolved in 10 ml of CH2Cl2 and then 1.2 mmol of triethylamine are added. The mixture is cooled with the aid of an ice bath and 1.2 mmol of ammonium hydroxide solution are added dropwise. After stirring for 2 hours, the mixture is evaporated and the residue obtained is recrystallised.

Workup

  1. temperatureThe mixture is cooled with the aid of an ice bath
  2. customthe mixture is evaporated
  3. customthe residue obtained
  4. customis recrystallised

Sources & evidence

ORD record
ord-49b40a4fb0d3447491c8b53f5e7ccd68
Source dataset
uspto-grants-2003_08
Patent number
US06605632B1

Reaction notes

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