HCID 86590365, compound → HCID 10179984, compound

HRID 395874Notes

Reaction equation

HRID 395874 reaction equation
FC(F)(F)C(O)=O.[CH3:8][N:9]([CH3:37])[CH2:10][CH2:11][CH:12]=[C:13]1[CH:18]2[CH:16]3[CH:17]2[CH2:19][CH:14]1[CH:15]3[C:20]1[NH:28][C:27]2[C:26](=[O:29])[N:25]([CH2:30][CH2:31][CH3:32])[C:24](=[O:33])[N:23]([CH2:34][CH2:35][CH3:36])[C:22]=2[N:21]=1>CCO.Cl.[Pt]>[CH3:37][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][CH:13]1[CH:18]2[CH:16]3[CH:17]2[CH2:19][CH:14]1[CH:15]3[C:20]1[NH:28][C:27]2[C:26](=[O:29])[N:25]([CH2:30][CH2:31][CH3:32])[C:24](=[O:33])[N:23]([CH2:34][CH2:35][CH3:36])[C:22]=2[N:21]=1

Participants

5

Reactant 1

HCID 86590365HCID 86590365, compound

Product 1

HCID 10179984HCID 10179984, compound

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

8-[5-(3-Dimethylamino-propylidene)-tricyclo[2.2.1.02,6]hept-3-yl]-1,3-dipropyl-3,7-dihydro-purine-2,6-dione; compound with trifluoro-acetic acid was hydrogenated under 60 psi using Pt/C 5% in EtOH (10 ml) and 1 ml conc. HCl overnight. Catalyst was filtered and solvent was removed under reduced pressure. Crude product was purified by HPLC Yield 30 mg. Mass (ES+ 414).

Workup

  1. filtrationCatalyst was filtered
  2. customsolvent was removed under reduced pressure
  3. customCrude product was purified by HPLC Yield 30 mg

Sources & evidence

ORD record
ord-bdd8e6ab50e64975b42b6a04d4480e05
Source dataset
uspto-grants-2003_08
Patent number
US06605600B1

Reaction notes

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