Lithium Hydroxide → HCID 10304359, compound

HRID 396064Notes

Reaction equation

HRID 396064 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:23][CH2:22][CH:21]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH:33][CH2:34][C@H:35]([OH:45])[CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=3)=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)=[O:17])[O:5][CH2:6][C:7]([O:9]C)=[O:8].[Li+].[OH-]>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:19][CH2:20][CH:21]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH:33][CH2:34][C@H:35]([OH:45])[CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=3)=[CH:27][CH:26]=2)[CH2:22][CH2:23]1)=[O:17])[O:5][CH2:6][C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 69987239HCID 69987239, compound

Product 1

HCID 10304359HCID 10304359, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl 2-(3-fluoro-4-{[({4-[4-(2-{[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino)ethyl)anilino]-1-piperidinyl}carbonyl)amino]methyl}phenoxy)acetate (0.107 g, 0.2 mmol) was dissolved in tetrahydrofuran. To this solution was added 1N LiOH (2 mL, 0.2 mmol) and stirred at ambient temperature for four days. The solvent was removed in vacuo and the resulting solid lyophilized to yield the title compound (0.075 g, 0.1 mmol).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-03c90b59070d4c33aa8b74a409bc421d
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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