(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal → Lactate

HRID 396118Notes

Reaction equation

HRID 396118 reaction equation
CC[C@@H]([C@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC([C@@H](N)CCCCN)=O)CSSC1)=O)C)=O)[C@H](O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)C)=O)CC(N)=O)=O)CC1C=CC=CC=1)=O)CC(C)C)=O)C(C)C)=O)CC1NC=NC=1)=O)CO)=O)CO)=O)CC(N)=O)=O)CC(N)=O)=O)CC1C=CC=CC=1)=O)=O)C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H:76]([C:85]([OH:87])=[O:86])[CH2:77]C1C=CC(O)=CC=1)=O)[C@H](O)C)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CC(N)=O)=O)[C@H](O)C)=O)CO)=O)CO)=O)CC(C)C)=O)C.[O:274]=[CH:275][C@@H:276]([C@H:278]([C@@H:280]([C@@H:282]([CH2:284][OH:285])[OH:283])[OH:281])[OH:279])[OH:277]>>[O:274]=[CH:275][C@@H:276]([C@H:278]([C@@H:280]([C@@H:282]([CH2:284][OH:285])[OH:283])[OH:281])[OH:279])[OH:277].[C:85]([O-:87])(=[O:86])[CH:76]([CH3:77])[OH:274]

Participants

4

Reactant 2

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 73355059HCID 73355059, compound3×

Product 2

HCID 91435LactateHCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

Procedure

At t=−30, vehicle, or amylin ±AC-0253 was begun. Amylin dose rates were 50, 100 and 300 pmol/kg/min. Dose rates of AC-0253 were 500 and 1500 pmol/kg/min. 25% glucose (1 gm/kg) was administered by mouth at t=0 minutes. Amylin±AC-0253 was discontinued at t=120 minutes. Samples for insulin, glucose and lactate were obtained at 15 minute intervals from t=−45 to t=180 minutes. Samples for rat amylin and AC-0253 were taken at t=60 and 120 minutes.

Workup

  1. customwas administered by mouth at t=0 minutes
  2. customwas discontinued at t=120 minutes

Sources & evidence

ORD record
ord-26af2c61a2804fc482de4a911e51e03a
Source dataset
uspto-grants-2003_08
Patent number
US06608029B1

Reaction notes

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