反应详情

温度

-20 °C

α-D-galactopyranosyl fluoride (2.30 g, 12.62 mmol) was dissolved in dry DMF (40 ml) and, at −20° C., benzyl bromide (12.95 g, 75.72 mmol) and silver oxide (10 g) were added. The reaction mixture was stirred at −20° C. for 5 h and then at room temperature for 24 h. The salts were then filtered off and the filtrate was evaporated in vacuo. The residue was purified by column chromatography on silica gel (350 g) with 15:1 petroleum ether/ethyl acetate.

1. waitat room temperature for 24 h
2. filtrationThe salts were then filtered off
3. customthe filtrate was evaporated in vacuo
4. customThe residue was purified by column chromatography on silica gel (350 g) with 15:1 petroleum ether/ethyl acetate