反应详情

5-amino-1-methyl-4-(4-methylphenyl)-1H-pyrazol-3-ol (Preparation 11) (305 mg) was dissolved in dimethylformamide (2 ml), potassium carbonate (622 mg) and 2-bromoethyl methyl ether (208 mg) were added. The reaction was stirred at room temperature for 1.5 hours and then at 50° C. for 12 hours. The solvent was removed under reduced pressure. The crude product was purified on silica (10 g) eluted with a solvent gradient of pentane:ethyl acetate (1:0 to 0:1) to yield the title compound as a white solid (201 mg).

1. waitat 50° C. for 12 hours
2. customThe solvent was removed under reduced pressure
3. customThe crude product was purified on silica (10 g)
4. washeluted with a solvent gradient of pentane:ethyl acetate (1:0 to 0:1)