Triethylamine → 5-Indanol

HRID 397913Notes

Reaction equation

HRID 397913 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([O:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:13])=[O:12])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C>CN(C1C=CN=CC=1)C.C(Cl)Cl>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([OH:10])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[F:15][C:14]([F:17])([F:16])[S:11]([O:10][S:11]([C:14]([F:17])([F:16])[F:15])(=[O:12])=[O:10])(=[O:13])=[O:12]

Participants

6

Reactant 2

HCID 8471TriethylamineHCID 85654274HCID 85654274, compound

Product 2

HCID 151185-IndanolHCID 67749Trifluoromethanesulfonic anhydride

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

The title compound, MS: m/e=244.1 (M+) was obtained as a light yellow oil (96% yield) using trifluoro-methanesulfonic acid indan-5-yl ester obtained in turn from indan-5-ol by treatment with trifluoro-methanesulfonic anhydride, DMAP and triethylamine in CH2Cl2 at −70° C. to 20° C.

Sources & evidence

ORD record
ord-bb73583ce76648fb9fd9f8cb6849ce22
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Reaction notes

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