Hydrochloric Acid → HCID 9939091, compound

HRID 397973Notes

Reaction equation

HRID 397973 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([O:16]CCC#N)=[O:15])=[C:12]([CH3:21])[NH:11][C:10]([CH2:22][O:23][CH2:24][CH2:25][CH:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)=[C:9]2[C:32]([O-])=[O:33])[CH:5]=[CH:6][CH:7]=1.CCN=C=NCCCN(C)C.Cl.[C:47]1([CH:53]([C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)[CH2:54][CH2:55][NH2:56])[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1.Cl>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:9]([C:32](=[O:33])[NH:56][CH2:55][CH2:54][CH:53]([C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)[C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=3)=[C:10]([CH2:22][O:23][CH2:24][CH2:25][CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]3)[NH:11][C:12]([CH3:21])=[C:13]2[C:14]([OH:16])=[O:15])[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 796983,3-DiphenylpropylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 86586640HCID 86586640, compound

Product 1

HCID 9939091HCID 9939091, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.25 g (0.51 mmol) of 5-(2-cyanoethyl) 4-(3-chlorophenyl)-2-(2-cyclohexylethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, 0.12 g (0.63 mmol) of WSC hydrochloride and 0.13 g (0.62 mmol) of 3,3-diphenylpropylamine were stirred together in 5 ml of dichloromethane at room temperature for 16 hours. 0.1 N hydrochloric acid was added to the reaction mixture. After the extraction with dichloromethane, the organic layer was concentrated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/1) to obtain the title compound.

Workup

  1. extractionAfter the extraction with dichloromethane
  2. concentrationthe organic layer was concentrated under reduced pressure
  3. customThe residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-2a14f2f9c6a84ce39c2c730153290f63
Source dataset
uspto-grants-2003_08
Patent number
US06610717B2

Reaction notes

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