反应详情

Gamma-methyl-L-glutamate N-carboxy anhydride ("MLGlu-NCA") was prepared from gamma-methyl-L-glutamic acid ("MLGlu"; the gamma --COOH group protected as the ester --COOCH3) and phosgene (COCl2) in tetrahydrofuran (THF) using the phosgene method. MLGlu-NCA (MW 187, 1.496 g, 8.0 mmol) was suspended in 10 mL of anhydrous ethylene dichloride ("EDC", ClCH2CH2Cl). N,N-dimethylethylenediamine ("N,N-DMEDA," 13.6 mg, 154 micromol) was added with vigorous stirring. As carbon dioxide (CO2) evolved, the MLGlu-NCA went slowly into solution and after 2 hours of mixing, a clear solution of poly(methyl-L-glutamate (i.e., "PMLGlu") has formed.

1. additionof mixing