反应详情

温度

40 °C

A mixture of methyl 5-tert-butoxycarbonylamino-3-pyridinecarboxylate (5.7 g) and conc. hydrochloric acid (11.4 ml) in methanol (57 ml) was stirred for 1 hour at 40° C. After being cooled to room temperature, the reaction mixture was poured into a mixture of ethyl acetate (100 ml) and water (50 ml) under stirring, and adjusted to pH 9.0 with 10% potassium carbonate aqueous solution. The organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was recrystallized from diethyl ether-methanol to afford methyl 5-amino-3-pyridinecarboxylate (2.03 g).

1. temperatureAfter being cooled to room temperature
2. stirringunder stirring
3. washThe organic layer was washed with brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated in vacuo
6. customthe residue was recrystallized from diethyl ether-methanol