反应详情

温度

140 °C

The mixture of methyl 4-hydroxy-3-(pyrrol-1-yl)benzoate (1.5 g), 2-oxo-1,3-dioxolane (0.61 g) and tetraethylammonium iodide (0.38 g) was heated at 140° C. for 3 hours. The resultant mixture was dissolved in the solution of ethyl acetate and tetrahydrofuran. The solution was washed with water and dried over magnesium sulfate. Evaporation of the solvent gave the residue, which was purified by column chromatography on silica gel eluting with the solution of chloroform and ethyl acetate (9:1, V/V). The eluted fractions containing the desired product were collected and evaporated in vacuo to give methyl 4-(2-hydroxyethoxy)-3-(pyrrol-1-yl)benzoate (1.25 g) as an oil.

1. washThe solution was washed with water
2. dry with materialdried over magnesium sulfate
3. customEvaporation of the solvent
4. customgave the residue, which
5. customwas purified by column chromatography on silica gel eluting with the solution of chloroform and ethyl acetate (9:1, V/V)
6. additionThe eluted fractions containing the desired product
7. customwere collected
8. customevaporated in vacuo