反应详情

温度

50 °C

6 mL benzyl bromide was added to 5 g azepane-4-one hydrochloride and 18.5 g potassium carbonate in 50 mL THF and 25 mL water. The mixture was stirred 5 h at 50° C., evaporated, diluted with water and extracted with ethyl acetate. The organic layer was evaporated. The residue was purified by chromatographie on silica gel (petrolether/ethyl acetate:8/2) to give 5 g of the desired product. Rf: 0.40 (hexane/ethyl acetate=1/1), (M+H)+=204

1. customevaporated
2. additiondiluted with water
3. extractionextracted with ethyl acetate
4. customThe organic layer was evaporated
5. customThe residue was purified by chromatographie on silica gel (petrolether/ethyl acetate:8/2)