Hydrochloric Acid → N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide

HRID 401134Notes

Reaction equation

HRID 401134 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[CH3:10][O:11][NH:12][CH3:13].CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.Cl>C(Cl)Cl.C([O-])(O)=O.[Na+].[Cl-].[Na+].O>[CH3:10][O:11][N:12]([CH3:13])[C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1

Participants

9

Reactant 5

HCID 313Hydrochloric AcidHCID 14232N,O-DimethylhydroxylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 234043-Thiophenacetic acidHCID 757711-Hydroxybenzotriazole

Product 1

HCID 11423995N-methoxy-N-methyl-2-(thiophen-3-yl)acetamideYield 76.6%

Reagents, catalysts & solvents 3

HCID 6344DichloromethaneSolvent2×HCID 516892Sodium BicarbonateSolventHCID 57417360Sodium chloride; waterSolvent

Procedure

A mixture of 2-(thiophen-3-yl)acetic acid (2.0 g, 14.1 mmol), O,N-dimethyl-hydroxylamine (1.68 g, 16.9 mmol), EDCI (2.95 g, 15.5 mmol), HOBT (2.15 g, 15.5 mmol), and TEA (3.7 mL, 31 mmol) in anhydrous DCM (50 mL) was stirred at room temperature under nitrogen for two hours. The reaction mixture was diluted with CH2Cl2, and the organic layer was washed with aqueous HCl solution (0.5 mol/L1, 30 mL×2), saturated NaHCO3 (30 mL×2) and brine (30 mL), dried over Na2SO4, filtered, and concentrated to give the crude N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide (2.0 g, yield 76.6%).

Workup

  1. dry with materialdried over Na2SO4
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-bc976ee6f9594c499e53b84a9e59c8ee
Source dataset
uspto-grants-2014_06
Patent number
US08741915B2

Reaction notes

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