Hydrochloric Acid → HCID 25109468, compound

HRID 402531Notes

Reaction equation

HRID 402531 reaction equation
COC1C=CC(C[N:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][C:12]([CH3:30])=[C:13]([O:18][CH:19]4[CH2:24][CH2:23][CH:22]([N:25]5[CH2:29][CH2:28][CH2:27][CH2:26]5)[CH2:21][CH2:20]4)[CH:14]=3)[C:9]2=[O:31])=CC=1.FC(F)(F)C(O)=O.Cl>>[CH3:30][C:12]1[CH:11]=[C:10]2[C:15]([CH:16]=[CH:17][NH:8][C:9]2=[O:31])=[CH:14][C:13]=1[O:18][CH:19]1[CH2:20][CH2:21][CH:22]([N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)[CH2:23][CH2:24]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 68553449HCID 68553449, compound

Product 1

HCID 25109468HCID 25109468, compoundYield 44.4%

Procedure

180 mg (0.4 mmol) of 2-(4-methoxy-benzyl)-7-methyl-6-(4-pyrrolidin-1-yl-cyclohexyloxy)-2H-isoquinolin-1-one were heated with 0.9 g trifluoro acetic acid in a microwave oven at 150° C. After aqueous workup, 58 mg of 7-methyl-6-(4-pyrrolidin-1-yl-cyclohexyloxy)-2H-isoquinolin-1-one were obtained as hydrochloride. Rt=1.07 min (Method B). Detected mass: 327.2 (M+H+).

Sources & evidence

ORD record
ord-3df29532843f4328b60ab9f36ebe0440
Source dataset
uspto-grants-2014_06
Patent number
US08742116B2

Reaction notes

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