反应详情

温度

70 °C

A solution of 4-(2-chloroethoxy)-2-methyl-1-nitrobenzene (2.1 g, 9.7 mmol), N-methylpiperazine (1.5 g, 15 mmol) and potassium carbonate (3.4 g, 0.025 mol) in N,N-dimethylformamide (15 mL) was stirred with heating at 70° C. for 18 h. Cooled to ambient temperature, the reaction mixture was poured into ice water, extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and concentrated. The residue was purified by chromatography on silica gel(dichloromethane/methanol) to afford 1-methyl-4-[2-(3-methyl-4-nitrophenoxy)ethyl]piperazine as solid (1.8 g, y. 64%).

1. temperatureCooled to ambient temperature
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water and brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customThe residue was purified by chromatography on silica gel(dichloromethane/methanol)