反应详情

温度

0 °C

8-Bromoquinolin-6-amine (300 mg, 1.34 mmol) was taken up in concentrated hydrochloric acid (8 ml) and cooled to 0° C. (ice bath). Sodium nitrite (1.86 gm, 26.9 mmol) was added in three equal portions over 10 minutes. The mixture was removed from the cooling bath and copper (I) chloride (3.33 g, 33.6 mmol) was added in 3 portions, over about 6 minutes. On stirring a green-black rising foam developed. Stirring was continued for 45 minutes and then the reaction mixture was cooled to 0° C. (ice bath). A mixture of ice water (75 ml) and ammonium hydroxide (75 ml) was added with vigorous stirring. Dichloromethane (150 ml) was added and the material was shaken in a reparatory funnel. The organic phase was collected and shaken with an equal volume of brine. The aqueous phases were back extracted with dichloromethane (2×120 ml). The organics were combined, dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product was purified by preparative thin layer chromatography (2 plates), eluting first with 1% methanol/dichloromethane and then re-developing the plate with 25% ethyl acetate/hexane. The product band was collected, providing the desired product as a light yellow-white solid (287 mg). (M+H)+=242/244 m/e.

1. additionwas added in 3 portions, over about 6 minutes
2. stirringStirring
3. temperaturethe reaction mixture was cooled to 0° C. (ice bath)
4. additionwas added with vigorous stirring
5. stirringthe material was shaken in a reparatory funnel
6. customThe organic phase was collected
7. stirringshaken with an equal volume of brine
8. extractionThe aqueous phases were back extracted with dichloromethane (2×120 ml)
9. dry with materialdried over magnesium sulfate
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customThe crude product was purified by preparative thin layer chromatography (2 plates)
13. washeluting first with 1% methanol/dichloromethane
14. customThe product band was collected