Hydrochloric Acid → HCID 68592745, compound

HRID 404745Notes

Reaction equation

HRID 404745 reaction equation
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([S:21][C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][C:31]=2[CH2:32][CH2:33][CH3:34])[CH:28]=[N:27][CH:26]=[CH:25]3)[CH2:17][CH2:16]1)=O)(C)(C)C.[ClH:35]>CC(O)C>[ClH:35].[NH:15]1[CH2:16][CH2:17][CH:18]([S:21][C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][C:31]=2[CH2:32][CH2:33][CH3:34])[CH:28]=[N:27][CH:26]=[CH:25]3)[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68593037HCID 68593037, compound

Product 1

HCID 68592745HCID 68592745, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

85 mg (107 mmol) 4-(7-Propyl-isoquinolin-6-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester trifluoroacetate (276) were stirred in 6N HCl in iPrOH for 1 h at RT. After evaporation water was added and lyophilized. 42 mg of 6-(Piperidin-4-ylsulfanyl)-7-propyl-isoquinoline hydrochloride were obtained. Rt=0.94 min (Method B). Detected mass: 287.1 (M+H+).

Workup

  1. customAfter evaporation water
  2. additionwas added

Sources & evidence

ORD record
ord-dfbc78cd55084523bdec11183235ce9c
Source dataset
uspto-grants-2014_06
Patent number
US08748614B2

Reaction notes

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