反应详情

温度

80 °C

Under an argon atmosphere a mixture of 0.28 g (0.97 mmol) (S)—N-[1-(4-iodo-phenyl)-ethyl]-acetamide (III.1), 0.20 g (0.98 mmol) 3-(4-tert-butyl-phenoxy)-azetidine, 0.0093 g (0.049 mmol) CuI, 0.41 g (1.95 mmol) K3PO4 and 0.12 g (1.95 mmol) ethyleneglycol in 1.0 mL isopropanol is stirred for 12 h at 80° C. 100 mL Ethyl acetate are added and the mixture is washed with ammonia solution (5%, 2×). The aq. layer is extracted with ethyl acetate (1×) and the combined organic layers are dried (MgSO4) and concentrated in vacuo. The residue is purified by HPLC (XBridge, MeOH/water (+0.3% NH4OH)) to yield the desired product.

1. washthe mixture is washed with ammonia solution (5%, 2×)
2. extractionThe aq. layer is extracted with ethyl acetate (1×)
3. dry with materialthe combined organic layers are dried (MgSO4)
4. concentrationconcentrated in vacuo
5. customThe residue is purified by HPLC (XBridge, MeOH/water (+0.3% NH4OH))