反应详情

温度

100 °C

3.60 g (18.6 mmol) 5-bromo-2-chloropyrimidine, 4.80 g (55.8 mmol) cyclopropyl boronic acid, 13.8 g (65.1 mmol) K3PO4,568 mg (2.03 mmol) tricyclohexylphosphine and 4 mL water are added to 80 mL toluene. The mixture is degassed thoroughly and charged with 627 mg (2.79 mmol) Pd(OAc)2. After degassing again the mixture is stirred at 100° C. over night, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc 90/10→70/30).

1. customThe mixture is degassed thoroughly
2. customAfter degassing again the mixture
3. filtrationfiltered
4. customthe solvent is removed in vacuo
5. customThe crude product is purified by column chromatography (silica gel, PE/EtOAc 90/10→70/30)