反应详情

温度

0 °C

To 2.30 g (10.4 mmol) 4-iodo-1H-pyridin-2-one in 130 mL DCM are added 0.88 mL (11.4 mmol) 2-propanol and 3.00 (11.4 mmol) triphenylphosphine. After cooling down to 0° C. 2.23 mL (11.4 mmol) DIAD are added dropwise. After 5 min the cooling is removed and the mixture is stirred at r.t. for 2 h. The reaction mixture is washed with water and brine, dried with Na2SO4 and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, heptane/EtOAc 90/10).

1. customAfter 5 min the cooling is removed
2. washThe reaction mixture is washed with water and brine
3. dry with materialdried with Na2SO4
4. customthe solvent is removed in vacuo
5. customThe crude product is purified by column chromatography (silica gel, heptane/EtOAc 90/10)