反应详情

0.51 g (S)-5-dibenzylaminopiperidin-2-one (see 5.1) are placed in 5 ml dimethylformamide. While cooling with the ice bath 120 mg sodium hydride (60% in mineral oil) are added. The reaction mixture is then stirred for 30 minutes at ambient temperature. While cooling with the ice bath 0.289 ml 1-iodopropane are added. The reaction mixture is then stirred overnight at ambient temperature, then combined with a saturated NaCl solution. The product is extracted with ethyl acetate. 0.569 g product are obtained as an oil.

1. additionare added
2. additionare added
3. stirringThe reaction mixture is then stirred overnight at ambient temperature
4. extractionThe product is extracted with ethyl acetate