反应详情

To a solution of rac-5-(7-ethoxy-7-oxoheptyl)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine-7,8-diyl diacetate (step 1) (30 mg, 0.054 mmol) in THF (3 ml) and water (1.0 ml) was added LiOH (7.70 mg, 0.322 mmol). The suspension was heated to reflux for 1 hour and allowed to stand at RT overnight. The mixture was again heated at reflux for 30 minutes and after cooling to RT, 1M HCl was added to adjust the pH to below pH 5. The volatile solvent was evaporated and the resulting mixture was extracted with EtOAc (10 ml). The organic extract was washed with water, dried over MgSO4, filtered and concentrated in vacuo to afford a mixture of the title products;

1. temperatureThe suspension was heated
2. temperatureto reflux for 1 hour
3. temperatureThe mixture was again heated
4. temperatureat reflux for 30 minutes
5. customThe volatile solvent was evaporated
6. extractionthe resulting mixture was extracted with EtOAc (10 ml)
7. extractionThe organic extract
8. washwas washed with water
9. dry with materialdried over MgSO4
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customto afford